|
T22749 |
DR2313
|
DR 2313 |
PARP
|
|
DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective. |
|
T50098 |
TIQ-A
|
|
PARP
|
|
TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m... |
|
T8964 |
G244-LM
|
|
Others
,
PARP
|
|
G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling. |
|
T16761 |
RK-287107
|
|
Others
,
PARP
|
|
RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively). |
|
T6842 |
G007-LK
|
|
PARP
,
Wnt/beta-catenin
|
|
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively. |
|
T15639 |
K-756
|
|
PARP
,
Wnt/beta-catenin
|
|
|
|
T2484 |
AZD-2461
|
|
PARP
|
|
AZD2461 is a novel PARP inhibitor. |
|
T6768 |
AZ6102
|
|
PARP
,
Wnt/beta-catenin
|
|
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells. |
|
T6181 |
UPF 1069
|
|
PARP
|
|
UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1. |
|
T6197 |
PJ34
|
|
PARP
|
|
PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2. |
|
T6578 |
ME0328
|
|
PARP
|
|
ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. |
|
T1807 |
JW 55
|
JW55 |
PARP
,
Wnt/beta-catenin
|
|
JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). |
|
T3168 |
MN-64
|
MN64 |
Others
,
PARP
,
Wnt/beta-catenin
|
|
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition. |
|
T21524 |
4-amino-1,8-Naphthalimide
|
|
PARP
|
|
4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM |
|
T22264 |
AZ9482
|
|
PARP
|
|
AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells. |
|
T7042 |
1,5-Isoquinolinediol
|
|
PARP
|
|
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol... |
|
T3062 |
WIKI4
|
|
PARP
,
Wnt/beta-catenin
|
|
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2). |
|
T5058 |
Pamiparib
|
BGB-290 |
PARP
|
|
Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor(IC50 of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively). It has potent PARP trapping, and capability to penetrate the brain, and can b... |
|
T6339 |
AG14361
|
AG 14361,AG-14361 |
PARP
|
|
AG14361 is an effective inhibitor of PARP1 (Ki<5 nM). |
|
T9165 |
AZD5305
|
|
PARP
|
|
AZD5305 is a potent, selective and oral active PARP inhibitor. |
|
T4472 |
NMS-P118
|
|
PARP
|
|
NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy. |
|
T4471 |
E7449
|
Stenoparib,UNII-9X5A2QIA7C |
Others
,
PARP
|
|
E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ～50 and ～50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. |
|
T9593 |
Senaparib
|
IMP4297 |
PARP
|
|
Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity. |
|
T22414 |
RBN012759
|
|
PARP
|
|
RBN012759, a potent and selective PARP14 inhibitor, decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants. |
|
T3649 |
BGP-15
|
BGP15,BGP-15 2HCl |
PARP
|
|
BGP-15 (BGP-15 2HCl) is a PARP inhibitor with protecting effect after ischemia-reperfusion injury. |
|
T12695 |
RBN-2397
|
|
PARP
|
|
RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM. |
|
T5399 |
GeA-69
|
|
PARP
|
|
GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays). |
|
T7896 |
BYK204165
|
RT-017290 |
PARP
|
|
BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay) |
|
T9497 |
Niraparib tosylate monohyrate
|
|
PARP
|
|
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting... |
|
T2124 |
PJ34 hydrochloride
|
PJ34 HCl |
PARP
|
|
PJ34 hydrochloride (PJ34 HCl) is a potent specific inhibitor of PARPl/2. |
|
T9430 |
Venadaparib
|
NOV140101,IDX-1197 |
PARP
|
|
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the... |
|
T7439 |
3-Methoxybenzamide
|
3-MBA |
PARP
,
Antibacterial
,
Transferase
|
|
3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase. |
|
T9024 |
OUL35
|
NSC39047 |
Others
,
PARP
|
|
OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death. |
|
T6912 |
NU1025
|
NSC 696807 |
PARP
|
|
NU1025 (NSC-696807) is a potent PARP inhibitor with IC50 of 400 nM. |
|
T1878 |
XAV-939
|
XAV939,NVP-XAV939 |
PARP
,
Wnt/beta-catenin
|
|
XAV-939 (NVP-XAV939) is a Tankyrase (TNKS) inhibitor that inhibits TNKS1 and TNKS2 (IC50=11/4 nM). XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription. |
|
T3261 |
NVP-TNKS656
|
TNKS656 |
Apoptosis
,
PARP
,
Wnt/beta-catenin
|
|
NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active TNKS2 inhibitor. |
|
T2591 |
Veliparib
|
ABT-888,NSC 737664 |
PARP
,
Autophagy
|
|
Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy. |
|
T6366 |
A-966492
|
|
PARP
|
|
A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively. |
|
T3231 |
Niraparib
|
MK-4827 |
Apoptosis
,
Others
,
PARP
|
|
Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis. |
|
T8806 |
Fluzoparib
|
HS10160,SHR3162 |
PARP
|
|
Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours. |
|
T12064 |
Niraparib (R-enantiomer)
|
MK 4827 (R-enantiomer),Niraparib R-enantiomer |
PARP
|
|
Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM). |
|
T16807 |
Rucaparib monocamsylate
|
Rucaparib Camsylate |
PARP
|
|
Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor (PARP1,Ki of 1.4 nM). Rucaparib Camsylate also displays binding affinity to eight other PARP domains. |
|
T3015 |
Olaparib
|
AZD2281,KU0059436 |
Mitophagy
,
PARP
,
Autophagy
|
|
Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and m... |
|
T6329 |
3-Aminobenzamide
|
3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001 |
PARP
|
|
3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion. |
|
T9891 |
PARP1-IN-8
|
N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide |
PARP
|
|
PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM). |
|
T60019 |
VPC-70063
|
Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- |
Apoptosis
,
PARP
,
c-Myc
|
|
VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C do... |
|
T2105 |
Veliparib dihydrochloride
|
ABT-888 dihydrochloride |
PARP
,
Autophagy
|
|
Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. |
|
T6941 |
PI-1840
|
PI 1840 |
PARP
,
Proteasome
|
|
PI-1840（IC50 = 27 nM）is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). |
|
T6253 |
Talazoparib
|
LT-673,BMN-673 |
PARP
|
|
Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM). |
|
T6224 |
Iniparib
|
NSC-746045,IND-71677,BSI-201 |
PARP
,
Influenza Virus
|
|
Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC). |
